Analysis of diffusion tensor parameters in spinocerebellar ataxia type 3 and type 10 patients.

ABSTRACT:

Introduction

There is a dearth of studies of spinocerebellar ataxias (SCAs) and diffusion tensor magnetic resonance imaging (DTI).

Objective

To analyze changes observed in DTI parameters and correlate these to clinical findings in SCA3 and SCA10 patients.

Methods

SCA3 (n = 19) and SCA10 (n = 18) patients were compared with a similar number of controls and assessed clinically and with the scale for the assessment and rating of ataxia (SARA) before undergoing the same MRI protocol. TRACULA (TRActs Constrained by UnderLying Anatomy) software was used to analyze the DTI metrics FA, AD, RD and MD.

Results

More white matter fiber tracts with changes in diffusivity were found in SCA3 patients than in SCA10 patients. There was a reduction in AD in altered fiber tracts

SUBMITTER: Meira AT 

PROVIDER: S-EPMC11571886 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature