Organ-specific Biodosimetry Modeling Using Proteomic Biomarkers of Radiation Exposure.

ABSTRACT: In future mass casualty medical management scenarios involving radiation injury, medical diagnostics to both identify those who have been exposed and the level of exposure will be needed. As almost all exposures in the field are heterogeneous, determination of degree of exposure and which vital organs have been exposed will be essential for effective medical management. In the current study we sought to characterize novel proteomic biomarkers of radiation exposure and develop exposure and dose prediction algorithms for a variety of exposure paradigms to include uniform total-body exposures, and organ-specific partial-body exposures to only the brain, only the gut and only the lung. C57BL6 female mice received a single total-body irradiation (TBI) of 2, 4 or 8 Gy, 2 and 8 Gy for lung or gut

SUBMITTER: Sproull M 

PROVIDER: S-EPMC11571893 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature