Numb and NumbL inhibit melanoma tumor growth by influencing the immune microenvironment.

ABSTRACT:

Objective

Many investigation have sought to identify therapeutic targets and treatment strategies for skin cutaneous melanoma (SKCM). Numb, an endocytic adaptor protein, is known to act as a tumor suppressor in various human cancers. However, the roles of Numb and its homolog NumbL in immune microenvironment, and their effect on melanoma remain largely unexplored.

Methods

We analyzed the expression levels of Numb and NumbL, as well as immune signatures of SKCM patients by UCSCXenaShiny v1 database. We also constructed animal model using Numb and NumbL conditional knockout (cKO) mice. Distribution analysis of immune cells in tumors was performed by flow cytometry and pathology staining.

Results

Numb and NumbL were found to be consistently expressed at low levels in SKC

SUBMITTER: Zhang S 

PROVIDER: S-EPMC11571900 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature