CD4+ T-cell transcription factors predict phenoconversion in idiopathic rapid eye movement sleep behavior disorder.

ABSTRACT: Aim: Early biomarkers of phenoconversion to neurodegeneration are crucial to identify individuals at high risk. In patients with idiopathic REM sleep behavior disorder (iRBD), the strongest risk factor for neurodegeneration, CD4⁺ T cells exhibit a peculiar transcription factor pattern.Objective: To assess transcription factor mRNA levels in CD4⁺ T cells as predictive biomarkers of phenoconversion in iRBD patients.Methods: iRBD patients were followed prospectively. ROC curve analysis and Kaplan-Meier curves were used to assess the discrimination between converters and non-converters.Results: CD4⁺ T cells from converters had higher STAT1, and lower GATA3 and FOXP3 mRNA levels. Hazard ratio was 58.3 (95% CI: 6.2

SUBMITTER: Pinoli M 

PROVIDER: S-EPMC11572078 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature