Cerebral blood flow alterations and host genetic association in individuals with long COVID: A transcriptomic-neuroimaging study.

ABSTRACT: Neuroimaging studies have indicated that altered cerebral blood flow (CBF) was associated with the long-term symptoms of postacute sequelae of SARS-CoV-2 infection (PASC), also known as "long COVID". COVID-19 and long COVID were found to be strongly associated with host gene expression. Nevertheless, the relationships between altered CBF, clinical symptoms, and gene expression in the central nervous system (CNS) remain unclear in individuals with long COVID. This study aimed to explore the genetic mechanisms of CBF abnormalities in individuals with long COVID by transcriptomic-neuroimaging spatial association. Lower CBF in the left frontal-temporal gyrus was associated with higher fatigue and worse cognition in individuals with long COVID. This CBF pattern was spatially associated with the

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11572096 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature