Clearance rate of contrast extravasation after endovascular therapy is associated with functional outcome and mediated by cerebral edema.

ABSTRACT: The brain's function of clearance and transport is closely related to the prognosis of acute ischemic stroke (AIS). In this study, we proposed a novel method, clearance rate of contrast extravasation (CROCE), to measure brain clearance and transport function in AIS patients undergoing endovascular therapy (EVT), and examined its association with cerebral edema and functional outcome. We conducted a pooled analysis of AIS patients of anterior circulation large vessel occlusion who underwent EVT in two academic hospitals. Patients who experienced contrast extravasation but not intracerebral hemorrhage following EVT were included. CROCE was defined as the mass of contrast agent cleared per hour on non-contrast CT (NCCT). Among the 215 patients finally included, we found that high CROCE was si

SUBMITTER: Luo J 

PROVIDER: S-EPMC11572124 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature