White matter hyperintensity shape is related to long-term progression of cerebrovascular disease in community-dwelling older adults.

ABSTRACT: White matter hyperintensity (WMH) shape is associated with long-term dementia risk in community-dwelling older adults, however, the underlying structural correlates of this association are unknown. We therefore aimed to investigate the association between baseline WMH shape and cerebrovascular disease progression over time in community-dwelling older adults. The association of WMH shape and cerebrovascular disease markers was investigated using linear and logistic regression models in the Age, Gene/Environment Susceptibility-Reykjavik (AGES) study (n = 2297; average time to follow-up: 5.2 years). A more irregular shape of periventricular/confluent WMH at baseline was associated with a larger increase in WMH volume, and with occurrence of new subcortical infarcts, new microbleeds, new enlar

SUBMITTER: Kuhn-Keller JA 

PROVIDER: S-EPMC11572234 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature