Development and Validation of a Culturally Adapted, Event-related Potential Paradigm for Assessing Alcohol Cue Reactivity and Error Processing in Alcohol Dependence.

ABSTRACT:

Background

Research on event-related potentials (ERP) in addiction highlights the importance of cognitive ERP markers, such as P300 and error-related negativity (ERN), in distinguishing between alcohol-dependent patients and healthy controls. We aimed to develop and validate ERP paradigms utilizing culturally validated stimuli to evoke P300 and ERN for the Indian population.

Methods

In a cross-sectional study, 16 alcohol-dependent patients and age-matched healthy controls were recruited. For P300, we designed a visual oddball (Go/No-Go) task using culturally appropriate alcohol and non-alcohol-related images. To study ERN, we used the Assessing Neurocognition via Gamified Experimental Logic (ANGEL) task, developed in India, integrating its "game" levels to capture error moni

SUBMITTER: Shenoy AA 

PROVIDER: S-EPMC11572319 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature