Comparative efficacy of <i>Knema retusa</i> extract delivery <i>via</i> PEG-<i>b</i>-PCL, niosome, and their combination against <i>Acanthamoeba triangularis</i> genotype T4: characterization, inhibition, anti-adhesion, and cytotoxic activity.

ABSTRACT:

Background

Acanthamoeba spp. is a waterborne, opportunistic protozoan that can cause amebic keratitis and granulomatous amebic encephalitis. Knema retusa is a native tree in Malaysia, and its extracts possess a broad range of biological activities. Niosomes are non-ionic surfactant-based vesicle formations and suggest a future targeted drug delivery system. Copolymer micelle (poly(ethylene glycol)-block-poly(ɛ-caprolactone); PEG-b-PCL) is also a key constituent of niosome and supports high stability and drug efficacy. To establish Knema retusa extract (KRe) loading in diverse nanocarriers via niosome, PEG-b-PCL micelle, and their combination and to study the effect of all types of nanoparticles (NPs) on Acanthamoeba viability,

SUBMITTER: Chimplee S 

PROVIDER: S-EPMC11572385 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature