Disease Activity and Bone Microarchitectural Phenotype in Patients With Axial Spondyloarthritis.

ABSTRACT:

Background

Axial spondyloarthritis (AxSpA) is a chronic rheumatic disease characterized by spine inflammation, abnormal bone growth, and paradoxically osteoporosis and vertebral fractures. The pathogenesis of skeletal deficits in this disease is poorly understood.

Purpose

We sought to evaluate volumetric bone mineral density (vBMD) and bone microarchitecture in patients with AxSpA and to identify disease-related factors associated with skeletal abnormalities.

Methods

We enrolled patients between 2018 and 2021 as part of a 2-year prospective study at a single institution investigating skeletal health and the skeletal effects of interleukin-17 (IL-17) treatment. Patients with AxSpA who met Assessment in SpondyloArthritis International Society (ASAS) classification crite

SUBMITTER: Russell L 

PROVIDER: S-EPMC11572425 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature