Different amyloid β42 preparations induce different cell death pathways in the model of SH-SY5Y neuroblastoma cells.

ABSTRACT: Amyloid β42 (Aβ42) plays a decisive role in the pathology of Alzheimer's disease. The Aβ42 peptide can aggregate into various supramolecular structures, with oligomers being the most toxic form. However, different Aβ species that cause different effects have been described. Many cell death pathways can be activated in connection with Aβ action, including apoptosis, necroptosis, pyroptosis, oxidative stress, ferroptosis, alterations in mitophagy, autophagy, and endo/lysosomal functions. In this study, we used a model of differentiated SH-SY5Y cells and applied two different Aβ42 preparations for 2 and 4 days. Although we found no difference in the shape and size of Aβ species prepared by two different methods (NaOH or NH₄OH for Aβ solubilization), we observed strong differences i

SUBMITTER: Ozdemir AY 

PROVIDER: S-EPMC11572474 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature