Study on the chemical stability of β-lactam antibiotics in concomitant simple suspensions with magnesium oxide.

ABSTRACT:

Background

A simple suspension method, where solid formulations are disintegrated and suspended by being soaked in warm water followed by tube administration, is widely used, especially for elderly patients with dysphagia in Japanese clinical settings. However, there is insufficient information on drug stability in the simple co-suspension of multiple formulations especially including acidic or alkaline ones. The influence of occasional prolonged soakage on drug stability is also of concern. In this study, the chemical stability of typical β-lactam antibiotics, amoxicillin, and cefcapene pivoxil hydrochloride, was investigated in simple co-suspensions with magnesium oxide (MgO), which is frequently used as an alkaline laxative for the elderly.

Methods

Amoxicillin (capsule) o

SUBMITTER: Kato G 

PROVIDER: S-EPMC11572518 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature