Improved reconstruction of crossing fibers in the mouse optic pathways with orientation distribution function fingerprinting.

ABSTRACT:

Purpose

The accuracy of diffusion MRI tractography reconstruction decreases in the white matter regions with crossing fibers. The optic pathways in rodents provide a challenging structure to test new diffusion tractography approaches because of the small crossing volume within the optic chiasm and the unbalanced 9:1 proportion between the contra- and ipsilateral neural projections from the retina to the lateral geniculate nucleus, respectively.

Methods

Common approaches based on Orientation Distribution Function (ODF) peak finding or statistical inference were compared qualitatively and quantitatively to ODF Fingerprinting (ODF-FP) for reconstruction of crossing fibers within the optic chiasm using in vivo diffusion MRI ( n = 18 $$ n=18 $$ healthy C57BL/6 mice). Manganese-

SUBMITTER: Filipiak P 

PROVIDER: S-EPMC11572703 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature