Impact of paramagnetic rim lesions on disability and race in multiple sclerosis: mediation analysis.

ABSTRACT:

Objective

Black American (BA) multiple sclerosis (MS) patients experience greater disability compared to White American (WA) patients. Here, we investigated the role of paramagnetic rim lesions (PRLs), a subset of chronic active lesions, on race-related disability in MS.

Methods

We conducted a retrospective observational study comparing BA and WA MS patients. PRLs were identified through Quantitative Susceptibility Mapping (QSM) MRI. A causal mediation analysis explored the impact of PRLs on the relationship between race and disability, as measured by the Expanded Disability Status Scale (EDSS).

Results

The prevalence of PRLs in BA patients with MS was higher at 55% compared to WA patients at 39% (p = 0.022). A higher percentage of PRLs among all white matter lesions

SUBMITTER: Michaelson NM 

PROVIDER: S-EPMC11572731 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature