Chronic active lesions preferentially localize in watershed territories in multiple sclerosis.

ABSTRACT:

Objective

Paramagnetic rim lesions (PRLs) are a biomarker of chronic active lesions (CALs), and an important driver of neurological disability in multiple sclerosis (MS). The reason subtending some acute lesions evolvement into CALs is not known. Here we ask whether a relatively lower oxygen content is linked to CALs.

Methods

In this prospective cross-sectional study, 64 people with multiple sclerosis (PwMS), clinically isolated syndrome and radiologically isolated syndrome underwent a 7.0 Tesla (7 T) brain magnetic resonance imaging (MRI). The scanning protocol included a T₂-w fluid-attenuated inversion recovery (FLAIR), and a single echo gradient echo from which susceptibility-weighted imaging (SWI) was derived. WM lesions were identified on the T₂-w-

SUBMITTER: Toubasi AA 

PROVIDER: S-EPMC11572742 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature