Insular monoaminergic deficits in prodromal α-synucleinopathies.

ABSTRACT:

Methods

This study assessed data from two cohorts of patients with alpha-synucleinopathies (University of Brescia and University of Rome Tor-Vergata cohorts). Consecutive participants with video-polysomnography-confirmed iRBD, Parkinson's disease (PD), dementia with Lewy bodies (DLB) and controls underwent neurological, clinical and ¹²³I-FP-CIT SPECT imaging assessments. Individuals with iRBD were longitudinally monitored to collect clinical phenoconversion to PD or DLB. The main outcome was to identify whole brain ¹²³ I-FP-CIT SPECT measures reflecting monoaminergic deficits in each clinical group as compared to controls.

Results

The cohort (n = 184) included 45 patients with iRBD, 47 PD, 42 DLB and 50 age-matched controls. Individuals with iRBD were c

SUBMITTER: Pilotto A 

PROVIDER: S-EPMC11572750 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature