Stress response regulation of mRNA translation: Implications for antioxidant enzyme expression in cancer.

ABSTRACT: From tumorigenesis to advanced metastatic stages, tumor cells encounter stress, ranging from limited nutrient and oxygen supply within the tumor microenvironment to extrinsic and intrinsic oxidative stress. Thus, tumor cells seize regulatory pathways to rapidly adapt to distinct physiologic conditions to promote cellular survival, including manipulation of mRNA translation. While it is now well established that metastatic tumor cells must up-regulate their antioxidant capacity to effectively spread and that regulation of antioxidant enzymes is imperative to disease progression, relatively few studies have assessed how translation and the hijacking of RNA systems contribute to antioxidant responses of tumors. Here, we review the major stress signaling pathways involved in translational regu

SUBMITTER: Kim YS 

PROVIDER: S-EPMC11572934 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature