Cholinergic regulation of dendritic Ca²⁺ spikes controls firing mode of hippocampal CA3 pyramidal neurons.

ABSTRACT: Active dendritic integrative mechanisms such as regenerative dendritic spikes enrich the information processing abilities of neurons and fundamentally contribute to behaviorally relevant computations. Dendritic Ca²⁺ spikes are generally thought to produce plateau-like dendritic depolarization and somatic complex spike burst (CSB) firing, which can initiate rapid changes in spatial coding properties of hippocampal pyramidal cells (PCs). However, here we reveal that a morpho-topographically distinguishable subpopulation of rat and mouse hippocampal CA3PCs exhibits compound apical dendritic Ca²⁺ spikes with unusually short duration that do not support the firing of sustained CSBs. These Ca²⁺ spikes are mediated by L-type Ca²⁺ channels and their time

SUBMITTER: Kis N 

PROVIDER: S-EPMC11572977 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature