Laparoscopic versus open pancreatoduodenectomy for periampullary tumors: a randomized clinical trial.

ABSTRACT:

Background

There is a lack of robust evidence on the efficacy of laparoscopic pancreatoduodenectomy compared to open surgery. This study was aimed to compare time to functional recovery (FR) between laparoscopic and open pancreatoduodenectomy.

Materials and methods

This pragmatic, multicenter, randomized controlled phase 3 trial was conducted in seven tertiary centers. Patients with periampullary tumors were randomized using a block design in a 1:1 ratio and stratified by pancreatic fistula risk. Participants were randomized to undergo open or laparoscopic pancreatoduodenectomy by expert pancreatic surgeons. The primary outcome was the time to FR, defined as the number of days until FR was achieved in all five domains. The secondary endpoints included perioperative and short

SUBMITTER: Yoon YS 

PROVIDER: S-EPMC11573048 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature