Association between serum Klotho and the prevalence of osteoarthritis: A cross-sectional study from NHANES 2007-2016.

ABSTRACT:

Background

Osteoarthritis (OA) is a degenerative joint disease prevalent in the elderly. Currently, the relationship between the senescence inhibitor Klotho and OA remains unclear. This study investigated the relationship between serum soluble Klotho (S-Klotho) and OA.

Methods

This cross-sectional study was based on the 2007-2016 National Health and Nutrition Examination Survey (NHANES). Three multifactorial logistic regression models were constructed to assess the association between serum Klotho and OA. Restricted cubic spline (RCS) curves were further used to assess whether there was a nonlinear relationship between serum Klotho and OA. Finally, stratified analyses and interaction tests were used to evaluate the association's stability. To further investigate the relation

SUBMITTER: Qiu Y 

PROVIDER: S-EPMC11573205 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature