Representing ECM composition and EMT pathways in gastric cancer using a new metastatic gene signature.

ABSTRACT:

Introduction

Gastric cancer (GC) is an aggressive and heterogeneous malignancy marked by cellular and molecular diversity. In GC, cancer cells invade locally in the stomach at stage I and can progress to metastasis in distant organs by stage IV, where it often becomes fatal.

Methods

We analyzed gene expression profiles from 719 stage I and stage IV GC patients across seven public datasets, conducting functional enrichment analysis to identify a gene signature linked to disease progression. Additionally, we developed an in vitro model of a simplified extracellular matrix (ECM) for cell-based assays.

Results

Our analysis identified a progression-associated gene signature (APOD, COL1A2, FSTL1, GEM, LUM, and SPARC) that characterizes stage IV GC. This signat

SUBMITTER: Albano F 

PROVIDER: S-EPMC11573575 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature