Lateral cell polarization drives organization of epithelia in sea anemone embryos and embryonic cell aggregates.

ABSTRACT: One of the first organizing processes during animal development is the assembly of embryonic cells into epithelia. Common features unite epithelialization across select bilaterians, however, we know less about the molecular and cellular mechanisms that drive epithelial emergence in early branching nonbilaterians. In sea anemones, epithelia emerge both during embryonic development and after cell aggregation of dissociated tissues. Although adhesion is required to keep cells together, it is not clear whether cell polarization plays a role as epithelia emerge from disordered aggregates. Here, we use the embryos of the sea anemone Nematostella vectensis to investigate the evolutionary origins of epithelial development. We demonstrate that lateral cell polarization is essential for epith

SUBMITTER: Atajanova T 

PROVIDER: S-EPMC11573592 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature