Use of low titer O whole blood in infants and young children undergoing cardiac surgery with cardiopulmonary bypass.

ABSTRACT:

Background

Low titer group O whole blood (LTOWB) is commonly used for severe bleeding in trauma patients. LTOWB may also benefit young children requiring cardiac surgery with cardiopulmonary bypass (CPB) at risk of severe bleeding.

Study design and methods

In this retrospective study, children <2 years old who underwent cardiac surgery with CPB were included. Comparisons were performed between those receiving component therapy (CT) versus those receiving LTOWB plus CT (LTOWB+CT). Outcomes included drainage tube (DT) output and total transfusion volumes. Optimization-based weighting was used for adjusted analyses between groups.

Results

There were 117 patients transfused with only CT and 127 patients transfused with LTOWB+CT. In the LTOWB+CT group, 66 were Group non-O

SUBMITTER: Griselli M 

PROVIDER: S-EPMC11573636 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature