Association of serum klotho with cognitive function among individuals with nonalcoholic fatty liver disease.

ABSTRACT:

Introduction

This study investigated the potential link between serum klotho levels and cognitive function in patients with non-alcoholic fatty liver disease (NAFLD).

Materials and methods

Utilizing NHANES data from 2011 to 2014, the research included 356 eligible participants. NAFLD was identified with the United States Fatty Liver Index (US-FLI), and cognition was measured by various tests including the Animal Fluency Test (AFT), Digit Symbol Substitution Test (DSST), Immediate Recall Test (IRT), and Delayed Recall Test (DRT). Weighted logistic regression and restricted cubic splines were employed to analyze the relationship between klotho levels and cognitive scores.

Results

A significant nonlinear association was observed between klotho levels and the performance

SUBMITTER: Wu F 

PROVIDER: S-EPMC11573754 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature