Modulatory Effect of Blood LDL Cholesterol on the Association between Cerebral Aβ and Tau Deposition in Older Adults.

ABSTRACT:

Background

This study investigates the synergistic relationship between blood low-density lipoprotein cholesterol (LDL-C) and cerebral beta-amyloid (Aβ) in relation to tau deposition, a key factor in the pathology of Alzheimer's disease (AD), in older adults across a diverse cognitive spectrum.

Objectives

To examine whether higher levels of LDL-C in the blood moderate the association of cerebral Aβ with tau deposition in older adults, including those with normal cognition, mild cognitive impairment, and Alzheimer's disease dementia.

Design

Cross-sectional design.

Setting

The study was conducted as a part of a prospective cohort study. All assessments were done at the Seoul National University Hospital, Seoul, South Korea.

Participants

A total of 136 olde

SUBMITTER: Han SM 

PROVIDER: S-EPMC11573824 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature