Population Pharmacokinetic Modelling of Norepinephrine in Healthy Volunteers Prior to and During General Anesthesia.

ABSTRACT:

Background

Intraoperation hypotension (IOH) is commonly observed in patients undergoing surgery under general anesthesia, and even a brief episode of IOH can lead to unfavorable outcomes. To reduce the risk, blood pressure is closely measured during general anesthesia, and norepinephrine (NE) is frequently administered if hypotension is detected. Despite its routine application, information on the dose-exposure-response relationship of NE remains limited. Additionally, quantification of the influence of general anesthesia on the pharmacokinetics (PK) of NE is lacking.

Objective

In this study, we aimed to describe NE PK in healthy volunteers and the influence of general anesthesia on its PK.

Methods

A single-center, cross-over study was conducted in healthy volunteers.

SUBMITTER: Li Y 

PROVIDER: S-EPMC11573843 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature