A Pilot Electroencephalography Study of the Effect of CT1812 Treatment on Synaptic Activity in Patients with Mild to Moderate Alzheimer's Disease.

ABSTRACT:

Background

CT1812 is a first-in-class, sigma-2 receptor ligand, that prevents and displaces binding of amyloid beta (Aβ) oligomers. Normalization of quantitative electroencephalography (qEEG) markers suggests that CT1812 protects synapses from Aβ oligomer toxicity.

Objectives

Evaluate CT1812 impact on synaptic function using qEEG measurements.

Design

Phase 2, randomized, double-blind, placebo-controlled, 4-week crossover study.

Setting

VU University Medical Center and Brain Research Center Amsterdam, The Netherlands.

Participants

Adults with mild or moderate Alzheimer's disease (AD).

Intervention

A daily 300 mg dose of CT1812 or placebo for 4 weeks.

Measurements

A resting-state, eyes closed qEEG assessment occurred on Day 1 and on Day 29 of

SUBMITTER: Vijverberg E 

PROVIDER: S-EPMC11573871 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature