Free Recall Outperforms Story Recall in Associations with Plasma Biomarkers in Preclinical Alzheimer Disease.

ABSTRACT:

Background

A decline in episodic memory is one of the earliest cognitive characteristics of Alzheimer disease and memory tests are heavily featured in cognitive composite endpoints that are used to demonstrate treatment efficacy. Assessments of episodic memory can take many forms including free recall, associate learning, and paragraph or story recall. Plasma biomarkers of Alzheimer disease are now widely available and will likely form the backbone of cohort enrichment strategies for future clinical trials. Thus, it is critical to evaluate which episodic memory measures are most sensitive to plasma markers of Alzheimer disease pathology.

Objectives

To compare the associations of common episodic memory tests with plasma biomarkers of Alzheimer disease.

Design

Longitudi

SUBMITTER: Aschenbrenner AJ 

PROVIDER: S-EPMC11573877 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature