A KNOX Ⅱ transcription factor suppresses the NLR immune receptor BRG8-mediated immunity in rice.

ABSTRACT: Nucleotide-binding site and leucine-rich repeat (NLR) proteins are activated by detecting pathogen effectors, which in turn trigger host defenses and cell death. Although many NLRs have been identified, the mechanisms responsible for NLR-triggered defense responses are still poorly understood. In this study, through a genome-wide association study approach, we identified a novel NLR gene, Blast Resistance Gene 8 (BRG8), which confers resistance to rice blast and bacterial blight diseases. BRG8 overexpression and complementation lines exhibit enhanced resistance to both pathogens. Subcellular localization assays showed that BRG8 is localized in both the cytoplasm and the nucleus. Additional evidence revealed that nuclear-localized BRG8 can enhance rice immunity without a hypersensitive resp

SUBMITTER: Xu S 

PROVIDER: S-EPMC11573908 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature