YTHDF1 boosts the lactate accumulation to potentiate cervical cancer cells immune escape.

ABSTRACT: Lactate is a major metabolic product of tumor cells in microenvironment. Increasing evidence has indicated that lactate accumulation could alter the immune response in human cancers, including cervical cancer. However, the function and significance of N⁶-methyladenosine (m⁶A) reader YTHDF1 in cervical cancer cells' lactate metabolism and immunotherapy remain obscure. Results illustrated that YTHDF1 predicted unfavorable clinical outcomes of cervical cancer, which was negatively correlated with CD8⁺ T cell infiltration. In the co-culture of tumor cells with CD8⁺ T cells, YTHDF1 overexpression promoted the lactate accumulation and attenuated the cytotoxic CD8⁺ T cell's killing effect. Correspondingly, YTHDF1 knockdown exerted the opposit

SUBMITTER: Xiong J 

PROVIDER: S-EPMC11573975 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature