Construction of molecular subtype and prognostic model for gastric cancer based on nucleus-encoded mitochondrial genes.

ABSTRACT: Gastric cancer (GC) is a common digestive system cancer, characterized by a significant mortality rate. Mitochondria is an indispensable organelle in eukaryotic cells. It was previously revealed that a series of nucleus-encoded mitochondrial genes (NMG) mutations and dysfunctions potentially contribute to the initiation and progression of GC. However, the correlation between NMG mutations and survival outcomes for GC patients is still unclear. In this study, NMG expression profile and clinical information in GC samples were collected from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Through consistent clustering and functional enrichment analysis, we have identified three NMG clusters and three gene clusters that are associated with patterns of immune cell in

SUBMITTER: Wang X 

PROVIDER: S-EPMC11574080 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature