A cross-tissue transcriptome-wide association study reveals GRK4 as a novel susceptibility gene for COPD.

ABSTRACT: Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory disorder with environmental factors being the primary risk determinants. However, genetic factors also substantially contribute to the susceptibility and progression of COPD. Although genome-wide association studies (GWAS) have identified several loci associated with COPD susceptibility, the specific pathogenic genes underlying these loci, along with their biological functions and roles within regulatory networks, remain unclear. This lack of clarity constrains our ability to achieve a deeper understanding of the genetic basis of COPD. This study leveraged the FinnGen R11 genetic dataset, comprising 21,617 cases and 372,627 controls, along with GTEx V8 eQTLs data to conduct a cross-tissue transcriptome-wide association

SUBMITTER: Chen G 

PROVIDER: S-EPMC11574126 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature