Honokiol protects against diabetic retinal microvascular injury via sirtuin 3-mediated mitochondrial fusion.

ABSTRACT:

Introduction

Mitochondrial dysfunction and oxidative stress play important roles in diabetic retinal vascular injuries. Honokiol (HKL) is a small-molecule polyphenol that exhibits antioxidant effects and has a beneficial effect in diabetes. This study aimed to explore the potential ability of HKL to ameliorate vascular injury in diabetic retinopathy (DR) and its possible mechanisms of action.

Methods

The effect of HKL was evaluated in vascular injury in an in vivo type 2 diabetic (db/db) mouse model. In vitro, retinal microvascular endothelial cells were treated with high glucose (HG) to simulate the pathological diabetic environment. Cell viability, expression of apoptosis-related proteins, cellular reactive oxygen species, mitochondrial membrane potential, an

SUBMITTER: Shi J 

PROVIDER: S-EPMC11574205 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature