Molecular profiles, sources and lineage restrictions of stem cells in an annelid regeneration model.

ABSTRACT: Regeneration of missing body parts can be observed in diverse animal phyla, but it remains unclear to which extent these capacities rely on shared or divergent principles. Research into this question requires detailed knowledge about the involved molecular and cellular principles in suitable reference models. By combining single-cell RNA sequencing and mosaic transgenesis in the marine annelid Platynereis dumerilii, we map cellular profiles and lineage restrictions during posterior regeneration. Our data reveal cell-type specific injury responses, re-expression of positional identity factors, and the re-emergence of stem cell signatures in multiple cell populations. Epidermis and mesodermal coelomic tissue produce distinct putative posterior stem cells (PSCs) in the emerging blastema. A no

SUBMITTER: Stockinger AW 

PROVIDER: S-EPMC11574210 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature