Developmental toxicity and mechanism of dibutyl phthalate on the development of subintestinal vessels in zebrafish.

ABSTRACT:

Background

The dibutyl phthalate (DBP) is a member of the phthalate family and is widely used as a plasticizer in daily life and production. However, the influence of DBP on the vascular developmental remains unclear.

Methods

In this study, we used zebrafish as a model organism to investigate the effects of DBP on vascular development in vivo. Death curves of zebrafish at different concentrations of DBP exposure and different times incubation were made firstly. Zebrafish embryos after fertilization for 5.5 h were exposed to different concentrations of DBP solution (0, 0.4, 0.8, 1.2 mg/L), the body length, yolk sac absorption area, mortality and heart rate of zebrafish were measured, and the number and area of sprouting of ventral vessels were quantified by transgenic fish sy

SUBMITTER: Peng W 

PROVIDER: S-EPMC11574295 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature