Maintenance immunosuppressive therapy in liver transplantation: results from CESIT study, an Italian retrospective cohort study.

ABSTRACT:

Objectives

To investigate the use of maintenance immunosuppressive treatments following liver transplantation and to compare their risk-benefit profiles in clinical practice.

Design

Retrospective multicentrer cohort study.

Setting

Four Italian regions (Lombardy, Veneto, Lazio, Sardinia).

Methods

Data were integrated from the national transplant information system and administrative claims data from four Italian regions. All adults who underwent incident liver transplantation between 2009 and 2019 were identified and categorised into two groups: cirrhosis or hepatocellular carcinoma (HCC). The trend of immunosuppressive treatment over years was analysed, and their effectiveness/safety profiles were compared using multivariate Cox models (HR; 95% CI).

Main out

SUBMITTER: Bellini A 

PROVIDER: S-EPMC11574479 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature