Consensus definition of a radiologically healed fistula on magnetic resonance imaging in perianal Crohn's disease: an international Delphi study.

ABSTRACT:

Introduction

Perianal fistulising Crohn's disease (pfCD) is a distinct and debilitating phenotype seen in around one-third of patients with CD. Clinical trials in pfCD are increasingly using magnetic resonance imaging (MRI) criteria as a primary endpoint, but there is heterogeneity in the radiological definition of a healed perianal fistula that currently limits our ability to perform meaningful meta-analyses of studies. Our aim is to standardise outcomes through the generation of an international consensus definition of a radiologically healed fistula.

Methods and analysis

This international Delphi consensus study employs a two-part strategy.The first is a systematic review to identify a longlist of variables used to define radiological healing in pfCD. MRI-based indices us

SUBMITTER: Anand E 

PROVIDER: S-EPMC11574496 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature