Inhibition of Cbl-b restores effector functions of human intratumoral NK cells.

ABSTRACT:

Background

T cell-based immunotherapies including immune checkpoint blockade and chimeric antigen receptor T cells can induce durable responses in patients with cancer. However, clinical efficacy is limited due to the ability of cancer cells to evade immune surveillance. While T cells have been the primary focus of immunotherapy, recent research has highlighted the importance of natural killer (NK) cells in directly recognizing and eliminating tumor cells and playing a key role in the set-up of an effective adaptive immune response. The remarkable potential of NK cells for cancer immunotherapy is demonstrated by their ability to broadly identify stressed cells, irrespective of the presence of neoantigens, and their ability to fight tumors that have lost their major histocompatibili

SUBMITTER: Tundo S 

PROVIDER: S-EPMC11574514 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature