Correction Rates and Clinical Outcomes in Hospitalized Adults With Severe Hyponatremia: A Systematic Review and Meta-Analysis.

ABSTRACT:

Importance

Hyponatremia treatment guidelines recommend limiting the correction of severe hyponatremia during the first 24 hours to prevent osmotic demyelination syndrome (ODS). Recent evidence suggests that slower rates of correction are associated with increased mortality.

Objective

To evaluate the association of sodium correction rates with mortality among hospitalized adults with severe hyponatremia.

Data sources

We searched MEDLINE, Embase, the Cochrane Library, LILACS, Web of Science, CINAHL, and international congress proceedings for studies published between January 2013 and October 2023.

Study selection

Comparative studies assessing rapid (≥8-10 mEq/L per 24 hours) vs slow (<8 or 6-10 mEq/L per 24 hours) and very slow (<4-6 mEq/L per 24 hours) correctio

SUBMITTER: Ayus JC 

PROVIDER: S-EPMC11574719 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature