A Combinatorial Functional Precision Medicine Platform for Rapid Therapeutic Response Prediction in AML.

ABSTRACT:

Background

Despite advances made in targeted biomarker-based therapy for acute myeloid leukemia (AML) treatment, remission is often short and followed by relapse and acquired resistance. Functional precision medicine (FPM) efforts have been shown to improve therapy selection guidance by incorporating comprehensive biological data to tailor individual treatment. However, effectively managing complex biological data, while also ensuring rapid conversion of actionable insights into clinical utility remains challenging.

Methods

We have evaluated the clinical applicability of quadratic phenotypic optimization platform (QPOP), to predict clinical response to combination therapies in AML and reveal patient-centric insights into combination therapy sensitivities. In this prospective

SUBMITTER: Sahib NRBM 

PROVIDER: S-EPMC11574777 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature