The brain topological alterations in the structural connectome and correlations with clinical characteristics in type 1 narcolepsy.

ABSTRACT:

Objective

To explore topological alterations of white matter (WM) structural connectome, and their associations with clinical characteristics in type 1 narcolepsy (NT1).

Methods

46 NT1 patients and 34 age- and sex-matched healthy controls were recruited for clinical data and diffusion tensor imaging collection. Using graph theory analysis, the topology metrics of structural connectome, rich club organization, and connectivity properties were compared between two groups. Furthermore, partial correlation analysis was performed between the network characteristics of 90 nodes or weakened edges and clinical data using Pearson or Spearman correlation, controlling by age and sex.

Results

Between-group comparison reflected that NT1 patients exhibited sleep disorders with como

SUBMITTER: Zhang H 

PROVIDER: S-EPMC11574789 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature