Integrated framework for quantitative T2-weighted MRI analysis following prostate cancer radiotherapy.

ABSTRACT:

Purpose

The aim of this study is to develop a framework for quantitative analysis of longitudinal T2-weighted MRIs (T2w) following radiotherapy (RT) for prostate cancer.

Materials and methods

The developed methodology includes: (i) deformable image registration of longitudinal series to pre-RT T2w for automated detection of prostate, peripheral zone (PZ), and gross tumor volume (GTV); and (ii) T2w signal-intensity harmonization based on three reference tissues. The REgistration and HARMonization (REHARM) framework was applied on T2w acquired in a clinical trial consisting of two pre-RT and three post-RT MRI exams. Image registration was assessed by the DICE coefficient between automatic and manual contours, and intensity normalization via i

SUBMITTER: Zacharaki EI 

PROVIDER: S-EPMC11574798 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature