Folate, alcohol, ADH1B and ALDH2 and colorectal cancer risk.

ABSTRACT:

Objective

There is limited evidence on the interaction by alcohol dehydrogenase 2 (ADH1B) (rs1229984) and aldehyde dehydrogenase 2 (ALDH2) (rs671) regarding the associations of alcohol and a methyl diet (low folate and high alcohol intake) with cancer risk, partly because of rare polymorphisms in Western populations.

Design

In a case-control study, we estimated the ORs and 95 % CIs to evaluate the associations of ADH1B and ALDH2 genotypes with colorectal cancer (CRC) and the joint association between methyl diets and ADH1B and ALDH2 polymorphisms with CRC risk using logistic regression models.

Setting

A hospital-based case-control study.

Participants

In total, 1001 CRC cases and 899 cancer-free controls admitted to two university hospitals.

Results

We fo

SUBMITTER: Seol JE 

PROVIDER: S-EPMC11574830 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature