One-Step Palladium-Catalyzed Heterocyclic Ring Closure of Benzofurans with Aryl Iodides through a Heck-Type Pathway.

ABSTRACT: An operationally simple and robust method for the direct arylation and ring closure of benzofurans is reported. Besides the mild conditions and good reaction yields, the methodology is applicable for a wide range of derivatives using commercially available aryl iodides with complete C₂ regioselectivity. The reaction is proposed to follow a Heck-type oxyarylation mechanism. The facile synthesis method will enable the development of new materials for diverse applications in biology and catalysis and as precursors for organic semiconductors.

SUBMITTER: Hassan F 

PROVIDER: S-EPMC11574844 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature