Synthesis of Thiaphenanthridinones from Sulfinate Esters and 2-Borylanilines.

ABSTRACT: A facile palladium-catalyzed synthesis of thiaphenanthridinones from sulfinate esters and 2-borylanilines is disclosed. Various sulfur analogs of phenanthridinones were synthesized by bromide-selective cross-coupling and cyclization in one step. Further transformations of the obtained thiaphenanthridinones allowed preparing a broad range of thiaphenanthridinone derivatives involving analogs of bioactive compounds.

SUBMITTER: Nakamura K 

PROVIDER: S-EPMC11574856 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature