The relationship between HBV antigens deposition in kidneys and renal prognosis in IgA nephropathy patients infected with HBV.

ABSTRACT:

Background

Hepatitis B virus (HBV) is a risk factor for the progression of immunoglobulin A (IgA) nephropathy. The effect of HBV antigens deposition in kidneys and treatment influencing HBV deposition requires further investigation.

Methods

We analyzed 198 patients with IgAN, including 99 patients with HBV infection and 99 propensity score-matched patients without HBV infection. The primary outcome was a composite of 30% decrease in eGFR from the baseline, kidney failure and all-cause mortality. A Cox proportional hazard model was used to assess the impact of both HBV positive in the serum and HBV antigens deposition in the kidneys on renal outcomes.

Results

Among 198 individuals, 27 primary composite outcome events were observed, of which 20 (20%) in the HBV positive

SUBMITTER: Guo Y 

PROVIDER: S-EPMC11574957 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature