MOSES: a methylation-based gene association approach for unveiling environmentally regulated genes linked to a trait or disease.

ABSTRACT:

Background

DNA methylation is a critical regulatory mechanism of gene expression, influencing various human diseases and traits. While traditional expression quantitative trait loci (eQTL) studies have helped elucidate the genetic regulation of gene expression, there is a growing need to explore environmental influences on gene expression. Existing methods such as PrediXcan and FUSION focus on genotype-based associations but overlook the impact of environmental factors. To address this gap, we present MOSES (methylation-based gene association), a novel approach that utilizes DNA methylation to identify environmentally regulated genes associated with traits or diseases without relying on measured gene expression.

Results

MOSES involves training, imputation, and association te

SUBMITTER: Kim S 

PROVIDER: S-EPMC11574994 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature