Formoterol dynamically alters endocannabinoid tone in the periaqueductal gray inducing headache.

ABSTRACT:

Background

Headache is a pain disorder present in populations world-wide with a higher incidence in females. Specifically, the incidences of medication overuse headache (MOH) have increased worldwide. Comorbidities of MOH include photosensitivity, anxiety, "brain fog", and decreased physical activity. The FDA-approved long-lasting selective β₂-adrenergic receptor agonist, formoterol, is currently approved for use in severe asthma and chronic obstructive pulmonary disease. Recently, interest in repurposing formoterol for use in other disorders including Alzheimer's disease, and neuropathic pain after spinal cord injury and traumatic brain injury has gained traction. Thus, revisiting known side-effects of formoterol, like headache and anxiety, could inform treatment paradi

SUBMITTER: Peterson IL 

PROVIDER: S-EPMC11575070 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature