Localization of brain neuronal IL-1R1 reveals specific neural circuitries responsive to immune signaling.

ABSTRACT: Interleukin-1 (IL-1) is a pro-inflammatory cytokine that exerts a wide range of neurological and immunological effects throughout the central nervous system (CNS) and is associated with the etiology of affective and cognitive disorders. The cognate receptor for IL-1, Interleukin-1 Receptor Type 1 (IL-1R1), is primarily expressed on non-neuronal cells (e.g., endothelial cells, choroidal cells, ventricular ependymal cells, astrocytes, etc.) throughout the brain. However, the presence and distribution of neuronal IL-1R1 (nIL-1R1) has been controversial. Here, for the first time, a novel genetic mouse line that allows for the visualization of IL-1R1 mRNA and protein expression (Il1r1^GR/GR) was used to map all brain nuclei and determine the neurotransmitter systems which express nIL-

SUBMITTER: Nemeth DP 

PROVIDER: S-EPMC11575132 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature