Protein phosphatase 1 suppresses PKR/EIF2α signaling during human cytomegalovirus infection.

ABSTRACT: Human cytomegalovirus (HCMV) is a ubiquitous pathogen that infects the majority of the world's population. Lytic HCMV replication in immunocompromised individuals or neonates can lead to severe disease in multiple organ systems and even death. The establishment of lytic replication is driven by the first viral proteins expressed upon infection, the immediate early proteins, which play a key role in creating an intracellular environment conducive to virus replication. Two immediate early proteins, the functional orthologs pTRS1 and pIRS1, stimulate immediate early gene expression by suppressing antiviral PKR/eIF2α signaling and enhance the translation of viral mRNAs independent of PKR antagonism. To better understand the molecular functions of pTRS1, we used proximity labeling proteomics to

SUBMITTER: Lenarcic EM 

PROVIDER: S-EPMC11575161 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature